-Genomic Data for WT1 Links
Protein
WT1
UniPROBE Accession Number
UP00627
Species
Homo sapiens
Domain
zf-C2H2
Swiss-Prot
P19544
Name and Synonyms
Name: Wilms tumor protein.
Synonyms:AWT1, GUD, NPHS4, WAGR, Wilms tumor protein, WIT-2, WT33
IHOP
93117
NCBI RefSeq
NP_000369
Description
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]
JASPAR
None Available
-PBM Motif Data for WT1_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CTCCCCC.C E.S. 0.494
G.GGGGGAG E.S. 0.494
Downloads
Download the zip of all WT1_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for WT1_F392L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
ATA.A.ATAA E.S. 0.463
TTAT.T.TAT E.S. 0.463
Downloads
Download the zip of all WT1_F392L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for WT1_H373Y_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
ATA.A.ATAA E.S. 0.475
TTAT.T.TAT E.S. 0.475
Downloads
Download the zip of all WT1_H373Y PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for WT1_R366C_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
CCCCCGCA E.S. 0.486
TGCGGGGG E.S. 0.486
Downloads
Download the zip of all WT1_R366C PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for WT1_R366L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
GCGGGGGA E.S. 0.485
TCCCCCGC E.S. 0.485
Downloads
Download the zip of all WT1_R366L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for WT1_R394L_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
ATA.A.ATAA E.S. 0.471
TTAT.T.TAT E.S. 0.471
Downloads
Download the zip of all WT1_R394L PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for WT1_R394W_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
ATA.A.ATAA E.S. 0.469
TTAT.T.TAT E.S. 0.469
Downloads
Download the zip of all WT1_R394W PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for WT1 (all alleles)
Downloads
Download the zip of all WT1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-WT1 Datasets
Clone Clone Type Last Modified Save View
WT1_REF DNA binding domain only search save
WT1_REF Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSRSD QLKRHQRRHT GVKPFQCKTC QRKFSRSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


WT1_F392L DNA binding domain only search save
WT1_F392L Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSRSD QLKRHQRRHT GVKPFQCKTC QRKLSRSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


WT1_H373Y DNA binding domain only search save
WT1_H373Y Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSRSD QLKRYQRRHT GVKPFQCKTC QRKFSRSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


WT1_R366C DNA binding domain only search save
WT1_R366C Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSCSD QLKRHQRRHT GVKPFQCKTC QRKFSRSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


WT1_R366L DNA binding domain only search save
WT1_R366L Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSLSD QLKRHQRRHT GVKPFQCKTC QRKFSRSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


WT1_R394L DNA binding domain only search save
WT1_R394L Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSRSD QLKRHQRRHT GVKPFQCKTC QRKFSLSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


WT1_R394W DNA binding domain only search save
WT1_R394W Insert Sequence
1    TLVRSASETS EKRPFMCAYP GCNKRYFKLS HLQMHSRKHT GEKPYQCDFK
51   DCERRFSRSD QLKRHQRRHT GVKPFQCKTC QRKFSWSDHL KTHTRTHTGE
101  KPFSCRWPSC QKKFARSDEL VRHHNMHQRN MTKLQLAL


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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