-Genomic Data for BCL6 Links
Protein
BCL6
UniPROBE Accession Number
UP00585
Species
Homo sapiens
Domain
zf-C2H2
Name and Synonyms
Name: B-cell lymphoma 6 protein.
Synonyms:B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL5, BCL-5, BCL-6, BCL6A, LAZ3, Protein LAZ-3, ZBTB27, Zinc finger and BTB domain-containing protein 27, Zinc finger protein 51, ZNF51
Description
Transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. An important function is to allow GC B-cells to proliferate very rapidly in response to T-cell dependent antigens and tolerate the physiological DNA breaks required for immunglobulin class switch recombination and somatic hypermutation without inducing a p53/TP53-dependent apoptotic response. In follicular helper CD4+ T-cells (T(FH) cells), promotes the expression of T(FH)-related genes but inhibits the differentiation of T(H)1, T(H)2 and T(H)17 cells. Also required for the establishment and maintenance of immunological memory for both T- and B-cells. Suppresses macrophage proliferation through competition with STAT5 for STAT-binding motifs binding on certain target genes, such as CCL2 and CCND2. In response to genotoxic stress, controls cell cycle arrest in GC B-cells in both p53/TP53-dependedent and -independent manners. Besides, also controls neurogenesis through the alteration of the composition of NOTCH-dependent transcriptional complexes at selective NOTCH targets, such as HES5, including the recruitment of the deacetylase SIRT1 and resulting in an epigenetic silencing leading to neuronal differentiation.
-PBM Motif Data for BCL6_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
TTC.AGGAA E.S. 0.498
TTCCT.GAA E.S. 0.498
Downloads
Download the zip of all BCL6_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for BCL6_H676Y_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
Save
Top Kmer
G.TAATTA.C E.S. 0.480
G.TAATTA.C E.S. 0.480
Downloads
Download the zip of all BCL6_H676Y PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for BCL6 (all alleles)
Downloads
Download the zip of all BCL6 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-BCL6 Datasets
Clone Clone Type Last Modified Save View
BCL6_REF DNA binding domain only search save
BCL6_REF Insert Sequence
1    TQSEYSDSSC ENGAFFCNEC DCRFSEEASL KRHTLQTHSD KPYKCDRCQA
51   SFRYKGNLAS HKTVHTGEKP YRCNICGAQF NRPANLKTHT RIHSGEKPYK
101  CETCGARFVQ VAHLRAHVLI HTGEKPYPCE ICGTRFRHLQ TLKSHLRIHT
151  GEKPYHCEKC NLHFRHKSQL RLHLRQKHGA ITNTKVQYRV SAT



BCL6_H676Y DNA binding domain only search save
BCL6_H676Y Insert Sequence
1    TQSEYSDSSC ENGAFFCNEC DCRFSEEASL KRHTLQTHSD KPYKCDRCQA
51   SFRYKGNLAS HKTVHTGEKP YRCNICGAQF NRPANLKTHT RIHSGEKPYK
101  CETCGARFVQ VAHLRAHVLI HTGEKPYPCE ICGTRFRHLQ TLKSHLRIHT
151  GEKPYHCEKC NLHFRHKSQL RLYLRQKHGA ITNTKVQYRV SAT



References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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