Protein Details

-Genomic Data for PHF1				Links
Protein PHF1	UniPROBE Accession Number UP01424	Species Homo sapiens	Domain Mtf2_C	Swiss-Prot O43189
Name and Synonyms Name: PHD finger protein 1. Synonyms:PCL1; PHF2; hPHF1; MTF2L2; TDRD19C; hPCI1; Polycomb-like protein 1				IHOP 90996
				NCBI RefSeq NP_077084
Description Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci. According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2. Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.				JASPAR None Available

-PBM Motif Data for PHF1_rep2
Primary Motif				Primary PWM Save
Primary Motif				Top Kmer AACCCGAC E.S. 0.476 GTCGGGTT E.S. 0.476
Secondary Motif				Secondary PWM Save
Secondary Motif				Top Kmer ATCGG..CCG E.S. 0.464 CGG..CCGAT E.S. 0.464
Downloads Download the zip of all PHF1_rep2 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-PBM Motif Data for PHF1_rep1
Primary Motif				Primary PWM Save
Primary Motif				Top Kmer GG..CCGACA E.S. 0.477 TGTCGG..CC E.S. 0.477
Secondary Motif				Secondary PWM Save
Secondary Motif				Top Kmer A..ACCCGCT E.S. 0.449 AGCGGGT..T E.S. 0.449
Downloads Download the zip of all PHF1_rep1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.

-PHF1 Datasets
Run name		PBM version	Save	View
PHF1_rep2		AMADID # 016060
PHF1_rep1		AMADID # 016060
Gene	Clone Type	Last Modified	Save	View
PHF1	Not full length	2017-09-07
PHF1 Insert Sequence `1 LSLPYGLKGL DWDAGHLSNR QQSYCYCGGP GEWNLKMLQC RSCLQWFHEA 51 CTQCLSKPLL YGDRFYEFEC CVCRGGPEKV RRLQLRWVDV AHLVLYHLSV 101 CCKKKYFDFD REILPFTSEN WDSLLLGELS DTPKGERSSR LLSALNSHKD 151 RFISGREIKK RKCLFGLHAR MPPPVEPPTG DGALTSFPSG QGPGGG`
References `Data are analyzed by array design with AMADID # 030236 in Li et al., Nature 2017`