- Protein
- SNAI2
|
- UniPROBE Accession Number
- UP00621
|
- Species
- Homo sapiens
|
- Domain
- zf-C2H2
|
- Swiss-Prot
- O43623
|
- Name and Synonyms
- Name: zinc finger protein SNAI2.
Synonyms:MGC10182, Neural crest transcription factor Slug, Protein snail homolog 2, SLUG, SLUGH, SLUGH1, WS2D, Zinc finger protein SNAI2
|
- IHOP
- 92263
|
- NCBI RefSeq
- NP_003059
|
- Description
- Transcriptional repressor that modulates both activator- dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1- induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2- box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis.
|
- JASPAR
-
None Available
|
