-Genomic Data for ESX1 Links
Protein
ESX1
UniPROBE Accession Number
UP00588
Species
Homo sapiens
Domain
Homeobox
Swiss-Prot
Q8N693
Name and Synonyms
Name: homeobox protein ESX1.
Synonyms:ESX1L, ESX1R, ESXR1, Extraembryonic, spermatogenesis, homeobox 1, Homeobox protein ESX1
IHOP
103233
Description
May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5'-TAATGTTATTA-3' which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover.
NCBI RefSeq
NP_703149
ESX1 DNA binding domain
1   RRYRICFTPI QLQELEAFFQ RVQYPDLFAR VELARRLGLP EPRVQVWFQN
51  RRAKWRR
JASPAR
None Available
-PBM Motif Data for ESX1_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
CTAATTAG E.S. 0.499
CTAATTAG E.S. 0.499
Downloads
Download the zip of all ESX1_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for ESX1_K193R_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
G.TAATTA.C E.S. 0.499
G.TAATTA.C E.S. 0.499
Downloads
Download the zip of all ESX1_K193R PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for ESX1 (all alleles)
Downloads
Download the zip of all ESX1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-ESX1 Datasets
Clone Clone Type Last Modified Save View
ESX1_REF DNA binding domain only search save
ESX1_REF Insert Sequence
1   GPQTAEGPQP PERKRRRRTA FTQFQLQELE NFFDESQYPD VVARERLAAR
51  LNLTEDRVQV WFQNRRAKWK RNQRVLMLRN TATADL


ESX1_K193R DNA binding domain only search save
ESX1_K193R Insert Sequence
1   GPQTAEGPQP PERKRRRRTA FTQFQLQELE NFFDESQYPD VVARERLAAR
51  LNLTEDRVQV WFQNRRARWK RNQRVLMLRN TATADL


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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