-Genomic Data for POU6F2 Links
Protein
POU6F2
UniPROBE Accession Number
UP00618
Species
Homo sapiens
Domain
POU
Swiss-Prot
P78424
Name and Synonyms
Name: POU domain, class 6, transcription factor 2.
Synonyms:POU domain, class 6, transcription factor 2, Retina-derived POU domain factor 1, RPF1, RPF-1, WT5, WTSL
IHOP
96276
NCBI RefSeq
NP_009183
Description
This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
JASPAR
None Available
-PBM Motif Data for POU6F2_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
GCTAATTA E.S. 0.498
TAATTAGC E.S. 0.498
Downloads
Download the zip of all POU6F2_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for POU6F2_E639K_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
G.TAATTA.C E.S. 0.497
G.TAATTA.C E.S. 0.497
Downloads
Download the zip of all POU6F2_E639K PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for POU6F2_L500M_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
A.CTAATTA E.S. 0.498
TAATTAG.T E.S. 0.498
Downloads
Download the zip of all POU6F2_L500M PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for POU6F2 (all alleles)
Downloads
Download the zip of all POU6F2 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-POU6F2 Datasets
Clone Clone Type Last Modified Save View
POU6F2_REF DNA binding domain only search save
POU6F2_REF Insert Sequence
1    SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL TQTQVGQALS
51   ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK LNPGLLYPAR
101  FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI GSEPSKKRKR
151  RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV VRVWFCNKRQ
201  ALKNTIKRLK QHEPATAV


POU6F2_E639K DNA binding domain only search save
POU6F2_E639K Insert Sequence
1    SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGL TQTQVGQALS
51   ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK LNPGLLYPAR
101  FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI GSEPSKKRKR
151  RTSFTPQALE ILNAHFEKNT HPSGQEMTKI AEKLNYDREV VRVWFCNKRQ
201  ALKNTIKRLK QHEPATAV


POU6F2_L500M DNA binding domain only search save
POU6F2_L500M Insert Sequence
1    SVGQLVSNPQ TAAGEVDGVN LEEIREFAKA FKIRRLSLGM TQTQVGQALS
51   ATEGPAYSQS AICRHTILRS HFFLPQEAQE NTIASSLTAK LNPGLLYPAR
101  FEKLDITPKS AQKIKPVLER WMAEAEARHR AGMQNLTEFI GSEPSKKRKR
151  RTSFTPQALE ILNAHFEKNT HPSGQEMTEI AEKLNYDREV VRVWFCNKRQ
201  ALKNTIKRLK QHEPATAV


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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