-Genomic Data for HLH-1 Links
Protein
HLH-1
UniPROBE Accession Number
UP00548
Species
C. elegans
Domain
bHLH
Name and Synonyms
Name: Helix Loop Helix Protein 1.
Synonyms:MyoD1
Description
hlh-1 encodes a basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the myogenic regulatory factor (MRF) subgroup of bHLH proteins; in C. elegans, HLH-1 activity is required during embryogenesis for proper bodywall muscle development and function, but not for bodywall muscle cell fate specification, per se: hlh-1 null mutants generate the normal number of bodywall muscle cells, but the arrangement of these cells is disrupted and mutant animals exhibit weak and disorganized muscle contractions; however, ectopic expression of HLH-1 in the embryo is sufficient to convert nearly all embryonic cell types to a bodywall muscle-like fate; in regulating bodywall myogenesis, genetic studies indicate that HLH-1 acts together with the UNC-120/SRF and HND-1/HAND transcription factors, both of which can also induce muscle-like fates when overexpressed in embryos; in addition, in some cell lineages, hlh-1 likely lies downstream of the PAL-1 homeodomain protein required for specification of the C and D founder cell fates; HLH-1 is expressed in nuclei and first appears in bodywall muscle precursors beginning at the ~80-cell stage of embryogenesis; expression then continues in these cells and their differentiated descendants throughout embryonic, larval, and adult stages of development.
-PBM Motif Data for HLH-1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
G.CAGCTG.C E.S. 0.498
G.CAGCTG.C E.S. 0.498
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
ASCAGCTGAC
GTCAGCTGST
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
RDCAGBTGBB
VVCAVCTGHY
Downloads
Download the zip of all HLH-1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for HLH-1_L13R
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
G.CACGTG.C E.S. 0.499
G.CACGTG.C E.S. 0.499
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
NNCACGTGNB
VNCACGTGNN
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
NVCACGTGNY
RNCACGTGBN
Downloads
Download the zip of all HLH-1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for HLH-1_L13T
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
ACAGCTG.C E.S. 0.482
G.CAGCTGT E.S. 0.482
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
AACACGTGTC
GACACGTGTT
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
RWCABVTGYB
VRCABVTGWY
Downloads
Download the zip of all HLH-1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for HLH-1_L13V
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
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Top Kmer
AACAG.TGT E.S. 0.498
ACA.CTGTT E.S. 0.498
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
VRCAGVTGDY
RHCABCTGYB
PBM-Derived DNA Binding Site Motif (BEEML-PBM)
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PWM
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Consensus
NNNNNNNNNN
NNNNNNNNNN
Downloads
Download the zip of all HLH-1 PBM files or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-HLH-1 Datasets
Clone Clone Type Last Modified Save View
HLH-1 Full length clone 2014-09-06 search save
HLH-1 Insert Sequence
1    MNTETSTQSA PSDTYDTSIY YNSSPRVTAN DITTLTSFAA PAPQVLDYAN
51   TQYDIYRNQP AYYLPSYAPT APTTFYSDFA NFNVTRSQDF ASVPAVANSS
101  DVKPIIIKQE KSTPNATELI IQSRVDSQHE DTTTSTAGGA GVGGPRRTKF
151  VLSVDRRKAA TMRERRRLRK VNEAFEVVKQ RTCPNPNQRL PKVEILRSAI
201  DYINNLERML QQAGKMTKIM EQNQHLQMTQ QINGAPPHDY VTSSHFASSS
251  YNPENMFDDD DLTDSDDDRD HHKLGNAVDL RRRNSLDRLS RIVASIPNEE
301  AMTDEQLLQP ANDVIDGEKK LEML



HLH-1_L13R Full length clone 2014-09-06 search save
HLH-1_L13R Insert Sequence
1    MNTETSTQSA PSDTYDTSIY YNSSPRVTAN DITTLTSFAA PAPQVLDYAN
51   TQYDIYRNQP AYYLPSYAPT APTTFYSDFA NFNVTRSQDF ASVPAVANSS
101  DVKPIIIKQE KSTPNATELI IQSRVDSQHE DTTTSTAGGA GVGGPRRTKF
151  VLSVDRRKAA TMRERRRRRK VNEAFEVVKQ RTCPNPNQRL PKVEILRSAI
201  DYINNLERML QQAGKMTKIM EQNQHLQMTQ QINGAPPHDY VTSSHFASSS
251  YNPENMFDDD DLTDSDDDRD HHKLGNAVDL RRRNSLDRLS RIVASIPNEE
301  AMTDEQLLQP ANDVIDGEKK LEML



HLH-1_L13T Full length clone 2014-09-06 search save
HLH-1_L13T Insert Sequence
1    MNTETSTQSA PSDTYDTSIY YNSSPRVTAN DITTLTSFAA PAPQVLDYAN
51   TQYDIYRNQP AYYLPSYAPT APTTFYSDFA NFNVTRSQDF ASVPAVANSS
101  DVKPIIIKQE KSTPNATELI IQSRVDSQHE DTTTSTAGGA GVGGPRRTKF
151  VLSVDRRKAA TMRERRRTRK VNEAFEVVKQ RTCPNPNQRL PKVEILRSAI
201  DYINNLERML QQAGKMTKIM EQNQHLQMTQ QINGAPPHDY VTSSHFASSS
251  YNPENMFDDD DLTDSDDDRD HHKLGNAVDL RRRNSLDRLS RIVASIPNEE
301  AMTDEQLLQP ANDVIDGEKK LEML



HLH-1_L13V Full length clone 2014-09-06 search save
HLH-1_L13V Insert Sequence
1    MNTETSTQSA PSDTYDTSIY YNSSPRVTAN DITTLTSFAA PAPQVLDYAN
51   TQYDIYRNQP AYYLPSYAPT APTTFYSDFA NFNVTRSQDF ASVPAVANSS
101  DVKPIIIKQE KSTPNATELI IQSRVDSQHE DTTTSTAGGA GVGGPRRTKF
151  VLSVDRRKAA TMRERRRVRK VNEAFEVVKQ RTCPNPNQRL PKVEILRSAI
201  DYINNLERML QQAGKMTKIM EQNQHLQMTQ QINGAPPHDY VTSSHFASSS
251  YNPENMFDDD DLTDSDDDRD HHKLGNAVDL RRRNSLDRLS RIVASIPNEE
301  AMTDEQLLQP ANDVIDGEKK LEML



References
Data are analyzed by array design with AMADID # 015681 in De Masi et al., NAR 2011


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