-Genomic Data for MSX2 Links
Protein
MSX2
UniPROBE Accession Number
UP00603
Species
Homo sapiens
Domain
Homeobox
Swiss-Prot
P35548
Name and Synonyms
Name: homeobox protein MSX-2.
Synonyms:CRS2, FPP, Homeobox protein Hox-8, Homeobox protein MSX-2, HOX8, MSH, PFM, PFM1
IHOP
90304
Description
Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antogonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter.
NCBI RefSeq
NP_002440
MSX2 DNA binding domain
1   RKPRTPFTTS QLLALERKFR QKQYLSIAER AEFSSSLNLT ETQVKIWFQN
51  RRAKAKR
JASPAR
None Available
-PBM Motif Data for MSX2_REF_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
A.CAATTAA E.S. 0.496
TTAATTG.T E.S. 0.496
Downloads
Download the zip of all MSX2_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for MSX2_REF_R2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
AA.CAATTA E.S. 0.497
TAATTG.TT E.S. 0.497
Downloads
Download the zip of all MSX2_REF PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for MSX2_P148H_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
CAATTA.T.A E.S. 0.494
T.A.TAATTG E.S. 0.494
Downloads
Download the zip of all MSX2_P148H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for MSX2_P148H_R2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
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PWM
Save
Top Kmer
A.TAATTA.G E.S. 0.495
C.TAATTA.T E.S. 0.495
Downloads
Download the zip of all MSX2_P148H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for MSX2_R172H_R2
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
ACCAATTA E.S. 0.499
TAATTGGT E.S. 0.499
Downloads
Download the zip of all MSX2_R172H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for MSX2_R172H_R1
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available. We apologize for the inconvenience.
PWM
Save
Top Kmer
TTAATTAA E.S. 0.498
TTAATTAA E.S. 0.498
Downloads
Download the zip of all MSX2_R172H PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for MSX2 (all alleles)
Downloads
Download the zip of all MSX2 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-MSX2 Datasets
Clone Clone Type Last Modified Save View
MSX2_REF DNA binding domain only search save
MSX2_REF Insert Sequence
1   SPTTCTLRKH KTNRKPRTPF TTSQLLALER KFRQKQYLSI AERAEFSSSL
51  NLTETQVKIW FQNRRAKAKR LQEAELEKLK MAAKP


MSX2_P148H DNA binding domain only search save
MSX2_P148H Insert Sequence
1   SPTTCTLRKH KTNRKPRTHF TTSQLLALER KFRQKQYLSI AERAEFSSSL
51  NLTETQVKIW FQNRRAKAKR LQEAELEKLK MAAKP


MSX2_R172H DNA binding domain only search save
MSX2_R172H Insert Sequence
1   SPTTCTLRKH KTNRKPRTPF TTSQLLALER KFRQKQYLSI AEHAEFSSSL
51  NLTETQVKIW FQNRRAKAKR LQEAELEKLK MAAKP


References
Data are analyzed by array designs with AMADID #s 030236, 015681 in Barrera et al., Science 2016


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