-Genomic Data for HLH-14 Links
Gene
hlh-14
Species
$species
Domain
bHLH
UniPROBE Accession Number
$accession_id
Synonyms
None Available
Description (from Wormbase)
hlh-14 encodes a basic helix-loop-helix (bHLH) transcription factor that is one of five C. elegans Achaete-Scute family homologs; HLH-14 activity is required generally for normal egg-laying, movement, body morphology, and larval development; more specifically, HLH-14 is required for proper neuronal development, particularly for regulation of the asymmetric cell division that gives rise to the PVQ/HSN/PHB neuroblasts and for normal differentiation of these neuroblast descendants, including their cell division patterns, migrations, and neurotransmitter expression; in specifying neuronal cell fates, genetic evidence suggests that hlh-14 acts together with hlh-2, which encodes the C. elegans E/Daughterless ortholog; HLH-14 is expresed exclusively in the embryo and detected in the left and right PVQ/HSN/PHB neuroblasts and their descendants, as well as in other cells identified, tentatively, as anterior neuroblasts and posterior neuroblasts such as Caapa.
-PBM Motif Data for HLH-14
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
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Top Kmer
AAAAAAAA E.S. 0.402
TTTTTTTT E.S. 0.402
Downloads
Download the zip of all HLH-14 PBM files or view the downloads directory for individual files.
-PBM Motif Data for HLH-2/HLH-14 Heterodimer
PBM-Derived DNA Binding Site Motif (Seed-And-Wobble)
Image Not Available.  We apologize for the inconvenience.
PWM
View
Top Kmer
ACA.CTGTC E.S. 0.488
GACAG.TGT E.S. 0.488
Downloads
Download the zip of all HLH-2/HLH-14 interaction files or view the downloads directory for individual files.
-HLH-14 Datasets
Gene Homodimerizes Clone Type Last Modified Save View
hlh-14 No Not full length 2014-07-16 search save
HLH-14 Insert Sequence
1    AKKNQVARNE RERKRVHQVN HGFDVLRNRL QPKNHTKKWS KADTLREAVK
51   YIQQLQVLLN QDPQQPSVSS STPDYTMNNS NNFNNYAVKE EFSMYLPQNY
101  CPQNQMSVPH GDVSHNFNSP TSSVSSSSYS PTQMCYPPVS YSNYPHH


Mutations away from WormBase HLH-14 wildtype:
• Methioinine start not included in insert sequence

HLH-14 Interacts With Clone Type Last Modified Save View
HLH-2 Full length clone 2008-07-23 search save
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