|
|
| -Genomic Data for Pparg |
Links |
- Protein
|
- UniPROBE Accession Number
- UP01350
|
- Species
- Mus musculus
|
- Domain
- NR,zf-C4
|
- Swiss-Prot
- P37238
|
- Name and Synonyms
- Name: nuclear receptor subfamily 1 group C member 3.
Synonyms:Nr1c3, Nuclear receptor subfamily 1 group C member 3, Peroxisome proliferator-activated receptor gamma, PPARgamma, PPAR-gamma, PPARgamma2, Ppar-gamma2, PPAR-gamma2
|
- IHOP
- 123693
|
- NCBI RefSeq
- NP_001120802
|
- Description
- Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (PubMed:19041764).
|
- JASPAR
-
None Available
|
|
