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| -Genomic Data for Srebf1 |
Links |
- Protein
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- UniPROBE Accession Number
- UP01393
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- Species
- Mus musculus
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- Domain
- HLH
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- Swiss-Prot
- Q9WTN3
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- Name and Synonyms
- Name: Sterol regulatory element-binding protein 1.
Synonyms:adipocyte determination- and differentiation-dependent factor 1 ADD1, ADD-1, bHLHd1, D630008H06, Srebp1, SREBP1, SREBP-1, SREBP-1a, SREBP1c, SREBP-1c, Sterol regulatory element-binding transcription factor 1
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- IHOP
- 124870
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- NCBI RefSeq
- NP_001300908
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- Description
- Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE- 1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC- 3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters.
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- JASPAR
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None Available
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| -PBM Motif Data for Srebf1 |
- PBM-Derived DNA Binding Site Motif
(Seed-And-Wobble)
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- PWM
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Save
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- Top Kmer
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TCACGTGA E.S. 0.499
TCACGTGA E.S. 0.499
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- Downloads
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Download the
zip
of all Srebf1 PBM files
or view the downloads directory for individual files.
Please note that the files which include probe sequence data are protected by an academic research use license,
which can be viewed here.
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| -Srebf1 Datasets |
| Gene |
Clone Type |
Last Modified |
Save |
View |
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Srebf1 |
DNA binding domain only |
2017-05-12 |
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- Srebf1 Insert Sequence
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1 AAGSKALGSA QSRGEKRTAH NAIEKRYRSS INDKIVELKD LVVGTEAKLN
51 KSAVLRKAID YIRFLQHSNQ KLKQENLTLR SAHKSK
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- References
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Data are analyzed by array designs with AMADID #s 016060, 015681 in Mariani et al., Cell Systems 2017
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