-Genomic Data for NKX2-5 Links
Protein
NKX2-5
UniPROBE Accession Number
UP01607
Species
Homo sapiens
Domain
Homeobox
Swiss-Prot
P52952
Name and Synonyms
Name: homeobox protein Nkx-2.5.
Synonyms:Cardiac-specific homeobox, CHNG5, CSX, CSX1, FLJ52202, FLJ97166, FLJ97195, FLJ97197, FLJ99536, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX2.5, NKX2E, NKX4-1
IHOP
87507
Description
This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.
NCBI RefSeq
NP_001159647
NKX2-5 DNA binding domain
1   RKPRVLFSQA QVYELERRFK QQRYLSAPER DQLASVLKLT STQVKIWFQN
51  RRYKCKR
JASPAR
None Available
-PBM Motif Data for NKX2-5_anti-GST_rep1
Primary Motif
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Primary PWM
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Top Kmer
C.TAAGTGG E.S. 0.497
CCACTTA.G E.S. 0.497
Secondary Motif
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Secondary PWM
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Top Kmer
GGTACTT.A E.S. 0.495
T.AAGTACC E.S. 0.495
Downloads
Download the zip of all NKX2-5_anti-GST_rep1 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for NKX2-5_anti-GST_rep2
Primary Motif
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Primary PWM
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Top Kmer
CCACTTGA E.S. 0.497
TCAAGTGG E.S. 0.497
Secondary Motif
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Secondary PWM
Save
Top Kmer
GGTACTTA E.S. 0.496
TAAGTACC E.S. 0.496
Downloads
Download the zip of all NKX2-5_anti-GST_rep2 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-PBM Motif Data for NKX2-5_1E6
Primary Motif
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Primary PWM
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Top Kmer
C..AAGTGGG E.S. 0.444
CCCACTT..G E.S. 0.444
Secondary Motif
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Secondary PWM
Save
Top Kmer
ATAT.ATAT E.S. 0.423
ATAT.ATAT E.S. 0.423
Downloads
Download the zip of all NKX2-5_1E6 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
Download Data for NKX2-5
Downloads
Download the zip of all NKX2-5 PBM files, or view the downloads directory for individual files. Please note that the files which include probe sequence data are protected by an academic research use license, which can be viewed here.
-NKX2-5 Datasets
Clone Clone Type Last Modified Save View
NKX2-5 Full length clone 2021-07-02 search save
NKX2-5 Insert Sequence
1    MFPSPALTPT PFSVKDILNL EQQQRSLAAA GELSARLEAT LAPSSCMLAA
51   FKPEAYAGPE AAAPGLPELR AELGRAPSPA KCASAFPAAP AFYPRAYSDP
101  DPAKDPRAEK KELCALQKAV ELEKTEADNA ERPRARRRRK PRVLFSQAQV
151  YELERRFKQQ RYLSAPERDQ LASVLKLTST QVKIWFQNRR YKCKRQRQDQ
201  TLELVGLPPP PPPPARRIAV PVLVRDGKPC LGDSAPYAPA YGVGLNPYGY
251  NAYPAYPGYG GAACSPGYSC TAAYPAGPSP AQPATAAANN NFVNFGVGDL
301  NAVQSPGIPQ SNSGVSTLHG IRAW


References
Data are analyzed by array design with AMADID # 030236 in Lai et al. 2020


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